Recent Publications

Winter UMN Campus


Samakkarnthai P, Saul D, Zhang L, Aversa Z, Doolittle ML, Sfeir JG, Kaur J, Atkinson EJ, Edwards JR, Russell RGG, Pignolo RJ, Kirkland JL, Tchkonia T, Niedernhofer LJ, Monroe DG, LeBrasseur NK, Farr JN, Robbins PD, Khosla S. In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529777. doi: 10.1101/2023.02.23.529777. PMID: 36865244; PMCID: PMC9980119.

Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. PMID: 36809340; PMCID: PMC10104901.

Henpita C, Vyas R, Healy CL, Kieu TL, Gurkar AU, Yousefzadeh MJ, Cui Y, Lu A, Angelini LA, O'Kelly RD, McGowan SJ, Chandrasekhar S, Vanderpool RR, Hennessy-Wack D, Ross MA, Bachman TN, McTiernan C, Pillai SPS, Ladiges W, Lavasani M, Huard J, Beer-Stolz D, St Croix CM, Watkins SC, Robbins PD, Mora AL, Kelley EE, Wang Y, O'Connell TD, Niedernhofer LJ. Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy. Aging Cell. 2023 Apr;22(4):e13782. doi: 10.1111/acel.13782. Epub 2023 Feb 3. PMID: 36734200; PMCID: PMC10086531.

Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. COVID-19 and cellular senescence. Nat Rev Immunol. 2023 Apr;23(4):251-263. doi: 10.1038/s41577-022-00785-2. Epub 2022 Oct 5. PMID: 36198912; PMCID: PMC9533263.


Carey A, Niedernhofer L, Camell C. Telomeres are a life-extending gift. Nat Cell Biol. 2022 Oct;24(10):1449-1450. doi: 10.1038/s41556-022-01004-9. PMID: 36168042.

Schmitt CA, Tchkonia T, Niedernhofer LJ, Robbins PD, Kirkland JL, Lee S. COVID-19 and cellular senescence. Nat Rev Immunol. 2022 Oct 5:1–13. doi: 10.1038/s41577-022-00785-2. Epub ahead of print. PMID: 36198912; PMCID: PMC9533263.

Schmitt CA, Tchkonia T, Niedernhofer LJ, et al. COVID-19 and cellular senescence. Nature reviews. Immunology. 2022 Oct. DOI: 10.1038/s41577-022-00785-2. PMID: 36198912; PMCID: PMC9533263.

Narasimhan A, Flores RR, Camell CD, Bernlohr DA, Robbins PD, Niedernhofer LJ. Cellular Senescence in Obesity and Associated Complications: a New Therapeutic Target. Curr Diab Rep. 2022 Nov;22(11):537-548. doi: 10.1007/s11892-022-01493-w. Epub 2022 Oct 14. PMID: 36239841.

Thompson, E. L.*, Pitcher, L. E.*, Niedernhofer, L. J. and Robbins, P. D.  (2022) Targeting Cellular Senescence with Senotherapeutics: Development of New Approaches for Skin Care.  Plastic & Reconstructive Surgery 150:12S-19S. doi: 10.1097/PRS.0000000000009668. PMID: 36170431

Soto-Palma C, Niedernhofer LJ, Faulk CD, Dong X. Epigenetics, DNA damage, and aging. J Clin Invest. 2022 Aug 15;132(16):e158446. doi: 10.1172/JCI158446. PMID: 35968782; PMCID: PMC9374376.

Zhang, L., Pitcher, L. E., Yousefzadeh, M. J., Niedernhofer, L. J., Robbins, P. D*. and Zhu, Y.* (2022) Cellular Senescence: A Key Therapeutic Target in Aging and Diseases, JCI 132:e158450. doi: 10.1172/JCI158450.PMID: 35912854 *Co-corresponding   

Saul, D.,  Kosinsky, R. L., Atkinson, E. J., Doolittle, M. L., LeBrasseur, N. K., Pignolo, R., Robbins, P. D., Niedernhofer, L. J., Ikeno, Y., Passos, J., Monroe, D. G., Tchkonia, T.,  Kirkland, J. L., Farr, J. N. and Khosla, S. (2022) A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues. Nature Comm. 13(1):4827. doi: 10.1038/s41467-022-32552-1. PMID: 35974106

Gullickson P, Xu YW, Niedernhofer LJ, Thompson EL, Yousefzadeh MJ. The Role of DNA Repair in Immunological Diversity: From Molecular Mechanisms to Clinical Ramifications. Front Immunol. 2022 Apr 1;13:834889. doi: 10.3389/fimmu.2022.834889. PMID: 35432317; PMCID: PMC9010869.

Masters, M. C.,  Landay, A. L., Robbins, P. D., Tchkonia, T.,  Kirkland, J. L., Kuchel, G. A., Niedernhofer, L. J., and Palella, F. J. Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach.  J. AIDs 89:S34-S46 doi:10.1097/QAI.0000000000002858. PMID: 35015744

Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting cellular senescence with senotherapeutics: senolytics and senomorphics. FEBS J. 2022 Jan 11. doi: 10.1111/febs.16350. Epub ahead of print. PMID: 35015337.

Yousefzadeh MJ, Robbins PD, Huffman DM. Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging. Aging (Albany NY). 2022 Apr 13;14(7):3325-3328. doi: 10.18632/aging.204015. Epub 2022 Apr 13. PMID: 35417855; PMCID: PMC9037264.

Chandra A, Lagnado AB, Farr JN, Doolittle M, Tchkonia T, Kirkland JL, LeBrasseur NK, Robbins PD, Niedernhofer LJ, Ikeno Y, Passos JF, Monroe DG, Pignolo RJ, Khosla S. Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity. Aging Cell. 2022 Apr 1:e13602. doi: 10.1111/acel.13602. Epub ahead of print. PMID: 35363946.


Tripathi, U., Nchioua, R.,  Langhi Prata, L, G. P.,  Zhu, Y.,  Wissler Gerdes, E. O.,  Giorgadze, N.,  Pirtskhalava, T.,  Espindola Netto, J. M., Xue, A., Deisinger, A. M.,  Stenger, S.,  Robbins, P. D.,  Niedernhofer, L. J.,  Ejima, K., Dickinson, S. L., Allison, D. B.,  Joshi, A.,  Kirchhoff, F.,  Johannes Sparrer, K. M.,  Tchkonia, T.,  Kirkland, J. L. SARS-CoV-2 Causes Senescence in Human Cells and Exacerbates the Senescence-Associated Secretory Phenotype Through TLR-3.  Aging, in press

Zhang, L.,  Zhao, J.,  Mu, X.,  McGowan, S. J.,  Angelini, L. A.,  O’Kelly, R. D.,  Yousefzadeh, M. J., Sakamoto, A., Aversa, Z., Lebrasseur, N. L., Suh, Y., Huard, J.,  Kamenecka, T. M.,  Niedernhofer, L. J. and Robbins, P. D. Novel small molecule inhibition of IKK/NF-kB activation reduces cellular senescence and improves healthspan in mouse models of accelerated and natural aging. Aging Cell, in press.

Lin, J. R., Sin-Chan, P., Mitra, J.,  Zhang, Q., Reza Jabalameli, M.,  Wang, Z.,  Nguyen, N., Gao, T., Holtzer, R., Ye, K., Shuldiner, A.,  Gorbunova, V.,  Ladiges, W. C.,  Niedernhofer, L. J.,  Robbins, P. D.,  Milman, S.,  Suh, Y.,  Vijg, J.,  Barzilai, N. and Z. D. Zhang.  Rare coding variants in conserved aging pathways contribute to human longevity and protection against AD and other age-related diseases.  Nature Agingin press

Evans, C. H., Ghivizzani, S. C and Robbins, P. D.  (2021) Orthopaedic gene therapy – 25 years on.  JBJS 26;9(8). doi: 10.2106/JBJS.RVW.20.00220.PMID: 34437305

Camell CD, Yousefzadeh MJ, Zhu Y, Langhi Prata LGP, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Machado Espindola-Netto J, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Senolytics reduce coronavirus-related mortality in old mice. Science. 2021 Jun 8:eabe4832. doi: 10.1126/science.abe4832. Epub ahead of print. PMID: 34103349.

Friedman J, Bird LM, Haas R, Robbins SL, Nahas SA, Dimmock DP, Yousefzadeh MJ, Witt MA, Niedernhofer LJ, Chowdhury S. Ending a diagnostic odyssey: Moving from exome to genome to identify cockayne syndrome. Mol Genet Genomic Med. 2021 Jun 2:e1623. doi: 10.1002/mgg3.1623. Epub ahead of print. PMID: 34076366.

Thompson EL, Hu JJ, Niedernhofer LJ. The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma. Cancers (Basel). 2021 May 7;13(9):2241. doi: 10.3390/cancers13092241. PMID: 34066966; PMCID: PMC8125319.

Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. An aged immune system drives senescence and ageing of solid organs. Nature. 2021 May 12. doi: 10.1038/s41586-021-03547-7. Epub ahead of print. PMID: 33981041.

Saccon TD, Nagpal R, Yadav H, Cavalcante MB, Nunes ADC, Schneider A, Gesing A, Hughes B, Yousefzadeh M, Tchkonia T, Kirkland JL, Niedernhofer LJ, Robbins PD, Masternak MM. Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice. J Gerontol A Biol Sci Med Sci. 2021 Jan 6:glab002. doi: 10.1093/gerona/glab002. Epub ahead of print. PMID: 33406219.

Yousefzadeh M, Henpita C, Vyas R, Soto-Palma C, Robbins P, Niedernhofer L. DNA damage-how and why we age? Elife. 2021 Jan 29;10:e62852. doi: 10.7554/eLife.62852. PMID: 33512317.

Huerta Guevara AP, McGowan SJ, Kazantzis M, Stallons TR, Sano T, Mulder NL, Jurdzinski A, van Dijk TH, Eggen BJL, Jonker JW, Niedernhofer LJ, Kruit JK. Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/- mice. Metabolism. 2021 Jan 22:154711. doi: 10.1016/j.metabol.2021.154711. Epub ahead of print. PMID: 33493548.

Robbins PD, Jurk D, Khosla S, Kirkland JL, LeBrasseur NK, Miller JD, Passos JF, Pignolo RJ, Tchkonia T, Niedernhofer LJ. Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:779-803. doi: 10.1146/annurev-pharmtox-050120-105018. Epub 2020 Sep 30. PMID: 32997601; PMCID: PMC7790861.


Lei C, Colangelo D, Patil P, Li V, Ngo K, Wang D, Dong Q, Yousefzadeh MJ, Lin H, Lee J, Kang J, Sowa G, Wyss-Coray T, Niedernhofer LJ, Robbins PD, Huffman DM, Vo N. Influences of circulatory factors on intervertebral disc aging phenotype. Aging (Albany NY). 2020 Jun 11;12(12):12285-12304. doi: 10.18632/aging.103421. Epub 2020 Jun 11. PMID: 32527988; PMCID: PMC7343497.

Yousefzadeh MJ, Wilkinson JE, Hughes B, Gadela N, Ladiges WC, Vo N, Niedernhofer LJ, Huffman DM, Robbins PD. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Geroscience. 2020 Jun;42(3):951-961. doi: 10.1007/s11357-020-00185-1. Epub 2020 Apr 13. PMID: 32285290; PMCID: PMC7286998.

Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. PMID: 32201398; PMCID: PMC7138542.

Yousefzadeh MJ, Zhao J, Bukata C, Wade EA, McGowan SJ, Angelini LA, Bank MP, Gurkar AU, McGuckian CA, Calubag MF, Kato JI, Burd CE, Robbins PD, Niedernhofer LJ. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. Aging Cell. 2020 Mar;19(3):e13094. doi: 10.1111/acel.13094. Epub 2020 Jan 25. PMID: 31981461; PMCID: PMC7059165.

Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Genetics of extreme human longevity to guide drug discovery for healthy ageing. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. PMID: 32719537; PMCID: PMC7912776.

Mu X, Tseng C, Hambright WS, Matre P, Lin CY, Chanda P, Chen W, Gu J, Ravuri S, Cui Y, Zhong L, Cooke JP, Niedernhofer LJ, Robbins PD, Huard J. Cytoskeleton stiffness regulates cellular senescence and innate immune response in Hutchinson-Gilford Progeria Syndrome. Aging Cell. 2020 Aug;19(8):e13152. doi: 10.1111/acel.13152. Epub 2020 Jul 25. PMID: 32710480; PMCID: PMC7431831.

Abdelgawad IY, Sadak KT, Lone DW, Dabour MS, Niedernhofer LJ, Zordoky BN. Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence. Pharmacol Ther. 2020 Dec 1;221:107751. doi: 10.1016/j.pharmthera.2020.107751. Epub ahead of print. PMID: 33275998.

Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30. PMID: 33378272; PMCID: PMC7803558.

Han Y, Zhou CM, Shen H, Tan J, Dong Q, Zhang L, McGowan SJ, Zhao J, Sowa GA, Kang JD, Niedernhofer LJ, Robbins PD, Vo NN. Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration. Aging Cell. 2020 Jul;19(7):e13162. doi: 10.1111/acel.13162. Epub 2020 Jun 21. PMID: 32567210; PMCID: PMC7406969.

Abdelgawad, I.Y., Sadak, K.T., Lone, D.W., Dabour, M.S., Niedernhofer, L.J. and B.N. Zordokay (2020) Molecular mechanisms and cardiovascular implications of cancer therapy-induced senescence. Pharmacol & Therapeutics (under review).

Guida, J.L., Agurs-Collins, T., Ahles, T.A., Campisi, J., Dale, W., Demark-Wahnefried, W., Dietrich, J., Fuldner, R., Gallicchio, L., Green, P.A., Hurria, A., Janelsins, M.C., Jhapppan, C., Kirkland, J.L., Kohanski, R., Longo, V., Meydani, S., Mohile, S., Niedernhofer, L.J., Nelson, C., Perna, F., Schadler, K.L. Scott, J.M., Schrack, J.A., Tracy, R.P., van Deursen, J. and K.K. Ness (2020) Strategies to prevent or remediate cancer and treatment-related aging. J Natl Cancer Inst. Doi: 1093/inci/djaa060. Online ahead or print. PMID: 32348501.

Zhang, Z., Milman, S., Lin, J-R. Barzilai, N., Wierbowski, S., Yu, H., Barzilai, N., Gorbunova, V., Ladiges, W.C., Niedernhofer, L.J., Suh, Y., Robbins, P.D. and J. Vijg (2020) Genetics of extreme human longevity to guide for drug discovery for healthy aging. Nat Metab. (accepted).

Justice, J.N., Niedernhofer, L.J., and M.E. Orr (2020) Senotherapeutics: Experimental therapy of cellular senescence. Handbook of the Biology of Aging. Elsevier, N.Y. editors: N. Musi and P. Hornsby.

Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. PMID: 32201398; PMCID: PMC7138542.

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Flores RR, Carbo L, Kim E, Van Meter M, De Padilla CML, Zhao J, Colangelo D, Yousefzadeh MJ, Angelini LA, Zhang L, Pola E, Vo N, Evans CH, Gambotto A, Niedernhofer LJ, Robbins PD. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice. FASEB J. 2019 Aug;33(8):9505-9515. doi: 10.1096/fj.201900420R. Epub 2019 Jun 6. PMID: 31170010; PMCID: PMC6662986.

Zhang L, Yousefzadeh MJ, Suh Y, Niedernhofer LJ, Robbins PD. Signal Transduction, Ageing and Disease. Subcell Biochem. 2019;91:227-247. doi: 10.1007/978-981-13-3681-2_9. PMID: 30888655.

Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Measuring biological age in mice using differential mass spectrometry. Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810. PMID: 30745468; PMCID: PMC6382423. 

Yousefzadeh MJ, Melos KI, Angelini L, Burd CE, Robbins PD, Niedernhofer LJ. Mouse Models of Accelerated Cellular Senescence. Methods Mol Biol. 2019;1896:203-230. doi: 10.1007/978-1-4939-8931-7_17. PMID: 30474850; PMCID: PMC7890466.

Yousefzadeh, M.J., Melos, K.I., Angelini, L., Burd, C.E., Robbins, P.D. and L.J. Niedernhofer (2019) Mouse models of accelerated cellular senescence. Methods Mol Biol. 1896:203-230. PMID:30474850.

Hambright, W.S., Niedernhofer, L.J., Huard, J. and P.D. Robbins (2019) Murine models of accelerated aging and musculoskeletal disease. Bone 125: 122-7.  PMID:30844492.

Fuhrmann-Stroissnigg, H., Santiago, F.E., Grassi, D., Ling, Y. Niedernhofer, L.J. and P.D. Robbins (2019) SA-β-Galactosidase-based screening assay for the identification of senotherapeutic drugs. J Vis Exp 148. PMID: 31305507.

Zhao, J., Gurkar, A. U., Niedernhofer, L. J. and P. D. Robbins (2019) Methods to quantify the NF-κB pathway during senescence.  Meth. Mol. Biol. 1896:231-250. PMID: 30474851.

Zhang, L., Yousefzadeh, M.J., Suh, Y., Niedernhofer, L.J. and P.D. Robbins (2019) Signal transduction, ageing and disease. Subcell Biochem. 91: 227-247. PMID 30888655.

Newman, J.C., Sokolski, J., Robbins, P. D., Niedernhofer, L.J., Reed, M., Wei, J., Austad, S., Barzilai, N. Cohen, H., Kuchel, G., Kirkland, J. and R. Pignolo (2019) Creating the next generation of translational geroscientists. J. Amer Geriat Soc. 67(9): 1934-1939. PMID: 31287934.

Gorgoulis, V., Adams, P.D., Alimonti, A., Bennett, D.C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A., N. Narita, M., Niedernhofer, L., Passos, J.F., Robbins, P.D., Schmitt, C.A., Sedivy, J., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M. and M. Demaria (2019) Cellular Senescence: Defining a Path Forward. Cell 179(4):813-827. PMID: 31675495.


Shanbhag NM, Geschwind MD, DiGiovanna JJ, Groden C, Godfrey R, Yousefzadeh MJ, Wade EA, Niedernhofer LJ, Malicdan MCV, Kraemer KH, Gahl WA, Toro C. Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F. Neurol Genet. 2018 Jun 8;4(3):e240. doi: 10.1212/NXG.0000000000000240. PMID: 29892709; PMCID: PMC5994703.

Czerwińska J, Nowak M, Wojtczak P, Dziuban-Lech D, Cieśla JM, Kołata D, Gajewska B, Barańczyk-Kuźma A, Robinson AR, Shane HL, Gregg SQ, Rigatti LH, Yousefzadeh MJ, Gurkar AU, McGowan SJ, Kosicki K, Bednarek M, Zarakowska E, Gackowski D, Oliński R, Speina E, Niedernhofer LJ, Tudek B. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation. Free Radic Biol Med. 2018 Aug 20;124:79-96. doi: 10.1016/j.freeradbiomed.2018.05.088. Epub 2018 Jun 1. PMID: 29860127; PMCID: PMC6098728.

Zarakowska E, Czerwinska J, Tupalska A, Yousefzadeh MJ, Gregg SQ, Croix CMS, Niedernhofer LJ, Foksinski M, Gackowski D, Szpila A, Starczak M, Tudek B, Olinski R. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009. doi: 10.1093/gerona/gly012. PMID: 29415265; PMCID: PMC6887695.

Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, Quarles EK, Robbins PD, Ladiges WC, LeBrasseur NK, Niedernhofer LJ. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging Cell. 2018 Apr;17(2):e12706. doi: 10.1111/acel.12706. Epub 2017 Dec 31. PMID: 29290100; PMCID: PMC5847863.

Mori T, Yousefzadeh MJ, Faridounnia M, Chong JX, Hisama FM, Hudgins L, Mercado G, Wade EA, Barghouthy AS, Lee L, Martin GM, Nickerson DA, Bamshad MJ; University of Washington Center for Mendelian Genomics, Niedernhofer LJ, Oshima J. ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes. Hum Mutat. 2018 Feb;39(2):255-265. doi: 10.1002/humu.23367. Epub 2017 Nov 17. PMID: 29105242; PMCID: PMC5762268.

Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D.P., McGowan, S.J., Corbo, L., Clemens, P.R., Wilson, G.M., Watkins, S.C., Solt, L.A., Cameron, M.D., Huard, J., Niedernhofer, L.J., Kamenecka, T.M. and P.D. Robbins (2018) Development of novel NEMO-Binding Domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 16(6):e2004663. PMID: 29889904.

Justice, J.N., Niedernhofer, L.J., Robbins, P.D., Aroda, V., Espeland, M.A., Kritchevsky, S.B., Kuchel, G.A., and N. Barzilai (2018) Development of clinical trials to extend healthy lifespan. Cardiovascular Endocrinol & Metab. 7(4):80-83. PMID: 30906924.

Niedernhofer, L.J. and P.D. Robbins (2018) Senotherapeutics for healthy ageing. Nat Rev Drug Discovery 17(5):377. PMID: 29651106.

Niedernhofer, L.J. Gurkar, A.U., Wang, Y., Vijg, J., Hoeijmakers, J.H.J. and P.D. Robbins (2018) Nuclear genomic instability and aging. Annual Rev Biochem 87:295-322. PMID: 29925262.

Sharma, K., Darvas, M., Keene, D., Niedernhofer, L.J. and W. Ladiges (2018) Modeling Alzheimer’s disease in progeria mice. An age-related concept. Pathobiol Aging Age Relat Dis. 8(1):1524815. PMID: 30319737.

Fuhrmann-Stroissnigg, H., Niedernhofer, L.J. and P.D. Robbins. (2018) Hsp90 inhibitors as senolytic drugs to extend healthy aging.  Cell Cycle doi: 10.1080/15384101.2018. PMID: 29886783.

Robinson, A.R. Yousefzadeh, M.J., Rozgaja, T.A., Wang, J., Wi, X. Tilstra, J.S., Feldman, C.H., Gregg, S.Q, Johnson, C.H., Skoda, E.M., Frantz, M-C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A.U., Nasto, L.A., Robinson, R.A.S., Fuhrmann-Stroissnigg, H., Czerwińska, J., McGowan, S.J., Cantu-Medillin, N., Harris, J.B., Maniar, S., Ross, M.A., Trussoni, C.E., LaRusso, N.F., Cifuentes-Pagano, E., Pagano, P.J., Tudek, B., Vo, N.V., Rigatti, L.H., Opresko, P.L., Stolz, D.B., Watkins, S.C., Burd, C.E., St. Croix, C.M., Siuzdak, G., Yates, N.A., Robbins, P.D., Wang, Y., Wipf, P., Kelley, E.E.*, and L.J. Niedernhofer* (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol. 17:259-273. *co-corresponding authors. PMID: 29747066.

Gurkar, A. U., Robinson, A.R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P.D., Wang, Y., Kelley, E.E., St. Croix, C.M.S., Niedernhofer, L. J.* and M.S. Gill* (2018) DNA damage drives aging via suppression of the mitochondrial unfolded protein response and DAF-16/FOXO3A activity. Redox Biol. 18:191-199. *co-corresponding authors PMID: 30031267.

Czerwińska, J., Nowak, M., Wojtczak, P., Dziuban-Lech, D., Cieśla, J.M., Kolata, D., Gajewska, B., Barańczyk-Kuźma, J., Robinson, A.R., Shane, H.L., Rigatti, L.H., Yousefzadeh, M.J., Gurkar, A.U., McGowan, S.J., Kosicki, K., Bednarek, M., Zarakowska, E., Gackowski, D., Oliῄski, R., Speina, E., Niedernhofer, L.J.* and B. Tudek* (2018) Lipid peroxidation-induced DNA damage promotes senescence, cell death and aging. Free Rad Biol Med. 124:79-96. *co-corresponding authors. PMID: 29860127.

Zarakowska, E., Czerwińska, J., Tupalska, A., Yousefzadeh, M.J., Gregg, S.Q., St. Croix, C.M., Niedernhofer, L.J., Foksiński, M., Gackowski, D., Szpila, A., Starczak, M., Tudek, B. and R. Oliński (2018) Oxidation products of 5-methylcytosine are decreased in senescent cells and tissues of progeroid mice. J Gerontol A Biol Sci Med Sci. 73(8): 1003-1009. PMID: 29415265.

Xu, M., Pirtskhalava, T., Farr, J.N., Weigand, B.M., Palmer, A.K., Weivoda, M.M., Inman, C.L., Ogrodnik, M.B., Hachfeld, C.M., Fraser, D.G., Onken, J.L., Johnson, K.O., Verzosa, G.C. Langhi, L.G.P., Weigl, M., Giorgadze, N., LeBrasseur, N.K., Miller, J.D., Jurk, D., Singh, R.J., Allison, D.B., Ejima, K., Hubbard, G.B., Ikeno, Y., Cubro, H., Garovic, V.D.,Hou, X., Weroha, S.J., Robbins, P.D., Niedernhofer, L.J., Khosla, S., Tchkonia, T. and J.L. Kirkland (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med. 24(8): 1246-1256. PMID: 29988130. 

Yousefzadeh, M.J., Zhu, Y., McGowan, S.J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y.Y., Melos, K.I., Portskhalava, T., Inman, C.L.,, McGuckian, C., Wade, E.A., Kato, J.I., Grassi, D., Wentowrth, M., Burd, C.E., Arriaga, E.A., Ladiges, W.L., Tchkonia, T., Kirkland, J.L., Robbins, P.D., and L.J. Niedernhofer (2018) Fisetin is a senotherapeutic that extends health and lifespan. EBiomedicine 36: 18-28. PMID: 30279143. 

Shanbhag, N.M., Geschwind, M., DiGiovanna, J.J., Groden, C., Godfrey, R., Yousefzadeh, M.J., Wade, E.A., Niedernhofer, L.J., Malicdan, M.C.V., Kraemer, K.H., Gahl, W.A., and C. Toro. (2018) Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F. Neurol Genet 4(3): e240. PMID: 29892709.

Patil, P., Niedernhofer, L.J., Robbins, P.D., Lee, J., Sowa, G. and N. Vo (2018 Cellular senescence in intervertebral disc aging and e12927. doi: 10.1111/acel.12927ngp. Curr Mol Biol Rep. 4(4):180-90. PMID: 3047991.

Hartman, R., Patil, P., Tisherman, R., St. Croix, C., Niedernhofer, L.J., Robbins, P.D., Ambrosio, F., van Houten, B., Sowa, G. and N. Vo (2018) Age-dependent changes in intervertebral disc cell mitochondria and bioenergetics. Eur Cell Mater. 36: 171-83. PMID: 30334244.